Protein Details: Voltage-gated sodium channel subunit beta-1
Protein ID
ICDB_Pro_0729
Protein Name
Voltage-gated sodium channel subunit beta-1
Gene Name
Scn1b
Organism
Rattus norvegicus (Rat)
Length
218 amino acids
AlphaFoldDB
AF-Q00954-F1-model_v4.pdb
Function
Regulatory subunit of multiple voltage-gated sodium channel complexes that play important roles in excitable membranes in brain; heart and skeletal muscle . Enhances the presence of the pore-forming alpha subunit at the cell surface and modulates channel gating characteristics and the rate of channel inactivation . Modulates the activity of a variety of pore-forming alpha subunits; such as SCN1A; SCN2A; SCN3A; SCN4A; SCN5A and SCN10A .
Sequence
MGTLLALVVGAVLVSSAWGGCVEVDSETEAVYGMTFKILCISCKRRSETTAETFTEWTFRQKGTEEFVKILRYENEVLQLEEDERFEGRVVWNGSRGTKDLQDLSIFITNVTYNHSGDYECHVYRLLFFDNYEHNTSVVKKIHLEVVDKANRDMASIVSEIMMYVLIVVLTIWLVAEMVYCYKKIAAATEAAAQENASEYLAITSESKENCTGVQVAE
PDB Structures
Ligand Binding
Binding Site
Disease
Location
Detected in brain (at protein level). Expressed in brain; heart; skeletal muscle and spinal cord. . . .
DOI ID
10.1126/science.1375395; 10.1101/gr.2596504
RefSeq
NP_001257974.1; NP_058984.1